Same Sex Marriage Should Be Legalized - 813 Words

Marriage is a choice. Some choose to be marry at an early age, and others choose to marry at some point in their lives. Some already planned when and where they will marry, others believe it will happen when the time comes. Some might not even believe in marriage at all. The opposing point of view of marriage between the religious and the non-religious has been going on for quite a while. It hasn’t been that long since the legalization of same sex marriage has been passed in some state. Meanwhile other states still question whether same sex marriage should be legalize. At the beginning of time, we based our morality and religious belief on The Bible. In modern society, it is arguable that marriage should only stay between man and woman. It is only natural to seek for someone to spend the rest of our lives with. Love then comes marriage. Although the term marriage has changed over time, it has always been a social or legal gatherings. Not long ago the term marriage is generally reserved for two individuals of opposite sex, of consenting age, and of no blood relation. Varied by different ethnicity or race, class, gender, social and economic standing, the right to marriage is only reserve for man and woman. The purpose of marriage is for reproduction and to maintain human society itself (Darity 612). Consequently when it comes to religious belief marriage it is seen as sacred and should be done traditionally, between man and woman. It is seen as a commitment to theirShow MoreRelatedShould Same-Sex Marriages Be Legalized?. Same-Sex Marriages2063 Words   |  9 PagesShould Same-Sex Marriages Be Legalized? Same-sex marriages should be illegal because the increase of marriages with the same sex has aroused conflicts in society, affects on children, and religiously. Therefore one must halt the proposal. The history of homosexuality has a lot of stories to tell, however, the beginning of it all would begin shortly and oddly. On the Western contemporary concept of homosexuality would relatively currently be considered new during the day of time. Ideas of homosexualityRead MoreSame Sex Marriage Should Be Legalized . The Same Sex Marriage1723 Words   |  7 Pages Same sex marriage should be legalized The same sex marriage has been widely debated in many countries for a long time. It is an important issue because it concerns basic moral and human rights. People all over the world come to the United States in search of freedom and equality. Being able to marry anyone, no matter the gender, is a freedom of right, but if that freedom of right is taken away from people than there is no equality. Homosexual peopleRead MoreSame Sex Marriage Should Not Be Legalized926 Words   |  4 Pageshave misunderstood the meaning of marriage. Marriage is not just a term to describe relationship that are precious to us, it’s more than just a union of heart and mind; it’s an institution between a man and a women. biblically, marriage is a life time union of a man and a women, primarily for the purpose of building a family and providing a stable environments for that family (1 Corinthian 7:2 16) According to Peter Sprigg, same sex marriage should not be legalized because of its immediate and long-termRead MoreSame Sex Marriage Should Be Legalized1361 Words   |  6 PagesSame sex marriage has been the topic of an ongoing controversial debate in many countries for a long time now. This is an important issue because it concerns the basic principle of human rights and basic morality. Same sex marriage should be legalized; it is a violation of human rights, there are many misconceptions of same sex individuals, and allowing same sex marriage to be legalized would provide a boost to the economy. There are many misconceptions of homosexual people. A common myth is thatRead MoreSame Sex Marriage Should Not Be Legalized1562 Words   |  7 Pages~ Busse Same-Sex Debate Essay ~ Ever since the time when America studied family values and focused on healthy and important influences, marriage was considered to be between man and woman holding a physical and spiritual bond between each other, not between man and man and woman and woman. Some may see marriage as between two people of the same gender, or what is known as same-sex marriage. This form of marriage became popular in the U.S. during the 1960’s and 1970’s due to the urge of legalizationRead MoreSame Sex Marriage Should Be Legalized898 Words   |  4 Pages2015 same sex marriage was legalized in all fifty states. Many arguments have come around about if homosexuality is genetic or if its chosen. Many people think either way and there aren’t many people who are in between thinking that homosexuality is chosen or not. The song â€Å"Same Love† by Macklemore was released in 2015 when all of the media slowed down about homosexuality and after same sex marriage was legalize d. So when Macklemore released this song more attention came to same sex marriage. ThisRead MoreShould Same Sex Marriage Be Legalized?1372 Words   |  6 PagesThe â€Å"date which will live in infamy† just had a child! As of June 26, 2015, same-sex marriage was legalized in all 50 states of America by the Supreme Court from a ruling that barely passed by a 5-4 vote. Wait a minute. Back up. Do you mean to tell me that boys can marry boys now? That girls can marry girls? That it’s legal?! Wake up America! Do you even realize what you have done? You have given gay people the right to marry. To marry! Who in their right mind would give gay people that cherishedRead MoreShould Same Sex Marriage Be Legalized?945 Words   |  4 PagesShould Same-Sex Marriage Be Legalized? Regardless of color, ethnicity, culture or religion, marriage has been and always have considered to be a man and a woman. This concern has been a debating and a hot topic currently in the United States p olitics, it is prohibited in a majority of the nation till the President have pass the law for same-sex marriage. With this question, I feel that same sex marriage should not be legalized, but it cannot be banned. I sense that a marriage is intensely betweenRead MoreSame Sex Marriage Should Be Legalized972 Words   |  4 PagesSame sex couples have been waiting for same sex marriage to be legalized for many decades. According to Ken LaMance, â€Å"One of the first documented challenges to same-sex marriages occurred on May 18th, 1970, where two men applied for a marriage license in Heppenin County, Minnesota† (LaMance). Their request was denied because they felt marriage should be between a man and a woman. Civil Unions were the first step in legalizing same sex marriage. Civil Unions were introduced in 2000 in Vermont. CivilRead MoreSame Sex Marriage Should Be Legalized910 Words   |  4 PagesSame-sex marriages also know, as gay/ Lesbian marriage is marriage between peop le of the same sex either as a secular civil ceremony or in a religious setting. In the late 20th century. Religious rites of marriage without legal recognition became increasingly common. In the 21st centuries various types of the same-sex unions have come to be legalized. As of 26 June 2015, eighteen countries; Argentina, Belgium, Brazil, Canada, Denmark, France, Iceland, Luxembourg, the Netherlands, New Zealand, Norway

Russia and Japan - 1271 Words

During the nineteenth century, Western Europe went through a marvelous era of industrialization and imperialism. This period of social, political, and territorial advancement caused a dramatic ripple-effect around the world, giving other countries such as Russia and Japan motivation to modernize. By 1914 Russia and Japan had managed to launch significant programs of industrialization and to make other changes designed to strengthen their political and social systems. These two nations defied the common pattern of growing Western domination during the nineteenth century. In the process, Japan pulled away from other Asian societies, while Russia ultimately enhanced its power in world affairs. Japan and Russia did have some common†¦show more content†¦It helped create a larger urban work force. Local rulers called zemstvoes regulated roads, schools, and regional policies. Military officers were chosen based on meritocracy, an idea adopted from the West. Increased literacy and l ooser values of sex were installed. Russian culture remained traditional and did not completely westernize. The tsar still viewed peasants as serfs that were inferior. The process of Russification spread the Russian language and Eastern Orthodox religion throughout the empire creating feelings of nationalism that united Russia as its own empire separate from the West. Russia’s attempt to industrialize created a stir in its heterogeneous society. Russia’s empire of many ethnic and revolutionary groups were not able to work together to modernize. A lack of food from inadequate farming technology led to frequent famines that angered peasants along with hefty redemption payments. The Intelligentsia group was most radical. Their intellectual radicalism inspired terrorism. They assassinated Tsar Alexander II and set out Pogroms against the Jews in Russia. The Intelligentsia wanted to industrialize but not become materialistic like the West. The anarchists wanted to abolish all formal government, especially the tsar. Marxists wanted a proletarian revolution without a middle class phase. Revolution was inevitable but these groups were not united and could be penalized harshly by Russia’sShow MoreRelatedDowntrodden Empires: Japan and Russia547 Words   |  2 PagesJapan and Russia both downtrodden empires under the shadow of Eur ope, industrialized to become global powers. After European’s show-off of force and political change, Russia used local resources and foreign loans while Japan used its own treasure and imported metals. Both industrialized in response to growing European dominance. Russia made its changes after the Crimean War. Not only did it lose but it lost to the inferior Ottomans who were backed up Europeans powers with rifles, cannons, and heavyRead MoreComparison Between Japan and Russia13811 Words   |  56 PagesCultural differences A comparison of Russia and Japan Kristina Aksakova Exchange student Virrat, 2011 [pic][pic] Table of contents General information about Russia and Japan 4 Japan 4 Background 4 Tsunami Devastates Japan 5 History 6 Geographical facts 8 Demographical facts 9 Economic facts 11 FOREIGN RELATIONS 13 Governmental facts 15 Infrastructural facts 16 Russia 18 Background 18 History 18 Geographical factsRead MoreIndustrialization Expansion in Russia and Japan Essay1050 Words   |  5 Pagesresources in a state. Some nations industrialized a while after Great Britain and were falling behind. Two of these states were Russia and Japan. These countries experienced change in governments, economic power, and social structure as a result of industrialization. Yet, these states went through their industrializations in very different ways than each other. Russia, industrialized as a result of many peasant revolts. The revolts led to the emancipation of the serfs in 1861, they received landRead MoreJapan s Victory Over Russia940 Words   |  4 PagesJapan’s victory over Russia made itself not only the most fearful colonial power in Asia, but also a world power that was respected by the Western world. The defeat in the Sino- Japanese War finally prompted both conservatives and liberals to consider reforms in both political and social domains as well reforms in the education system. China was in a precarious political situation where elements of both Confucianism and Western institutions were coexisting side by side. Between June 11 and SeptemberRead MoreThe War Between Tsarists Russia And The Empire Of Japan2450 Words   |  10 Pages Prepared By: Joseph Coccia Submitted To: Dr. Eric Ash Course: Regional History 5333: The Soviet Union Virtual Campus, Summer Session Due date: May 10, 2015 The 1904-1905 war between Tsarists Russia and the Empire of Japan pitted a newly developed modern military against and poorly funded, organized, and outdated war machine. It to become the bloodiest war fought prior to World War I. The conflict gained universal recognition as the Russo-Japanese War. The Russians desired to expandRead More Leadership Traits in Europe, Russia, and Japan Essay2772 Words   |  12 Pagesdoctrine and a rigid sociopolitical hierarchy exerting monopoly control over resources and the means of production. Until recently, only a select body of the Supreme Soviet or its appointees had authority to make substantive decisions. Today, however, Russia is attempting to denationalize its economy. The transformation is accompanied by a mandate to reposition companies as market-driven enterprises. Consequently, managers are gaining expanded responsibility for organizational performance. Managers areRead MoreComparing Japan and Russias Response to industrialization befo re 1914.1519 Words   |  7 Pagesinfiltrating Russia. The French Plague was a gradual move towards freedom and a more influential say in government. Russia avoided the French Plague by a period of isolation and oppression of their people. Japan also had a long period of isolation. The Japanese believed in the Mandate of Heaven or that there culture was the best. Because of their ethnocentric culture, only one Japanese port, Nagasaki, was open to traders once a year. During the late 19th century, both Russia and Japan were forcedRead MoreThe Japanese War Of Japan1680 Words   |  7 Pages Introduction: The Russo-Japanese War was important for propelling Japan forward to becoming a very powerful country in the world. Japan did win the war, but it was a difficult was for both countries involved. It was a war fought for expansion, power, and economic gain. Background Information: Japan was a rising power. It was a country getting more powerful mainly because of the Meiji restoration, which lasted from 1868 to 1912. It had recently won a war against China that lastedRead MoreThe Rise Of The Late And Early 20th Century1693 Words   |  7 PagesCountries such as Japan, Russia, as well as Europe’s scramble for Africa are prime examples of existing legacies from the imperialistic era of the late 19th century and onto the early 20th century. A balance of imperial expansion and their eventual collapse were the key components utilized by Western nations to modernize and westernize the world between the periods of 1850 and 1950. Perhaps the most dramatic example of a country highly influenced by Western ideals was Japan in the early 20th CenturyRead MoreThe Factors and Objectives The Russo Japanese War1019 Words   |  4 Pagessouthwestern portion of Japan). 2. The principle parties in this war were the Russian and Japanese Empires. While various aspects of the Chinese Empire played their roles in the lead-up to the conflict they did not, however, side with either of the two warring Empires during the war. Russia did have an alliance of sorts with France and Germany, however, this advantage in numbers was negated due to Japan’s formal alliance with Great Britain, who declared support for Japan should a third party become

Literary Analysis The Kite Runner And Oedipus Rex

The Kite Runner Oedipus Rex: Literary Analysis Essay Although The Kite Runner and Oedipus Rex differ from the style in which they were written and by the authors who wrote them what they do share are common themes. Both the play and the book share two major subject matters. Guilt is one theme that is seen constantly between Amir dealing with it in The Kite Runner written by Khaled Hosseini and Oedipus and Jocasta’s struggle with it in Oedipus Rex written by Sophocles. Another theme found in both texts was strained family dynamics which shows readers a different look on family. The themes in the book and the play, although they are portrayed differently, both deal with family relationships, guilt and why it is significant from the†¦show more content†¦He was picked up and cared for by another family who he grew up thinking were his parents. This being said Oedipus did not have a relationship with his biological parents in a usual way. Oedipus married his mother Jocasta but at the time was not aware she was his mother a nd together they had children. Furthermore, the four children half girls half boys were developed through incest. To add to the dysfunction Oedipus figured out you cannot run from fate because he did kill Laius not knowing that was his father. This play transcends that not all families are perfect and hidden behind a â€Å"white picket fence† perfect, happy family there could be a mess that cannot be picked up and fixed. Another theme that was in both The Kite Runner and Oedipus Rex was guilt. Guilt in The Kite Runner is something that Amir knew all too well. Amir felt guilty from the very beginning of his life when his mother died during the childbirth and it got even worse when he thought Baba resented him. Amir’s guilt went to a new level when he witnessed Hassan being raped by Assef and did nothing to stop the situation except for running away. Adding on to the guilt, Amir had to deal with it after Ali and Hassan moved out because he contributed to the fact by letting Hassan take the blame for something that he did, straining once great relationships to non-existing relationships. Guilt did not just play a part in The KiteShow MoreRelatedDeveloping Management Skills404131 Words   |  1617 PagesLine 58 Understanding and Appreciating Individual Differences Important Areas of Self-Awareness 61 Emotional Intelligence 62 Values 65 Ethical Decision Making and Values 72 Cognitive Style 74 Attitudes Toward Change 76 Core Self-Evaluation 79 SKILL ANALYSIS 84 Cases Involving Self-Awareness 84 Communist Prison Camp 84 Computerized Exam 85 Decision Dilemmas 86 SKILL PRACTICE 89 Exercises for Improving Self-Awareness Through Self-Disclosure 89 Through the Looking Glass 89 Diagnosing Managerial Characteristics

Media Censorship - 1427 Words

April 30, 2011 Media Censorship in the United States Censorship has existed for longer than we could ever imagine. One of the first acts of state sponsored censorship occurred in 399 B.C. when Socrates, was executed for the â€Å"supposed common good of the people† (Guarding Public Morality, 2010, p.1). Socrates was a teacher and a philosopher in ancient Greece. His teaching methods were controversial for the time, and he was charged with corrupting the youth and drawing them away from the Greek religion. As a result of his actions, Socrates was sentenced to death by drinking a poisonous liquid containing hemlock (Guarding Public Morality, 2010, p. 1). As a teacher, Socrates had many students and one of those students, the Greek†¦show more content†¦This increase in violence and aggression leads to more crimes being committed by adults. This thinking leads to the theory that if there was more censorship, there would be less violence on television, and there would be less crimes being committed (Arguments Favoring, 2009, p.1). Those who are for media censorship are mostly conservatives who feel that violence and vulgarity should not be on the television because a child is likely to accidently or even purposely click over to that channel. Children’s critical thinking skills are not fully developed and they cannot comprehend information the way that adults do. Essentially, they feel that media censorship is essential in society to protect children from lost moral values (Arguments Favoring, 2009, p.1). On the other side of the debate, those against censorship of television feel that it is a violation of the Freedom of Speech which is the first amendment of the United States Constitution (Anti-Censorship, p.1). They argue that â€Å"Freedom of Speech is a basic human right, and that this should not be eroded or compromised through censorship in a nation which likes to call itself free† (Wilson, 2010, p.1). They also argue that the Freedom of Speech was not put into place to protect only the speech that the majority of people agreed with, rather it was put into place to protect the speech and opinions of all Americans (Anti-Censorship, p.2). Those against television censorship feel that it isShow MoreRelatedCensorship in the Media1115 Words   |  5 PagesIs Censorship necessary? â€Å"Once a government is committed to the principle of silencing the voice of opposition, it has only one way to go, and that is down the path of increasingly repressive measures, until it becomes a source of terror to all its citizens and creates a country where everyone lives in fear. -- Harry S Truman Thesis: Although some people believe that censorship is adequate to select what things does the society will be good and can live around it while others believe that thereRead MoreCensorship and Indecency in Media928 Words   |  4 PagesCensorship and Indecency in Media Although indecent speech is protected by the First Amendment speech in broadcast media has been restricted because of its accessibility to children. In Federal Communications Commission’s (FCC) current policy, indecent speech is defined as the â€Å"language that describes, in terms patently offensive as measured by contemporary community standards for the broadcast medium, sexual or excretory activities and organs, at times of the day when there is a reasonable thatRead MoreCensorship Of The Media By Herbert Foerstel3055 Words   |  13 Pagescovered such expression about any government officials† [Foerstel, 1998: 4] Censorship of the media - as described by Herbert Foerstel - took shape during the reign of King Edward I. Ever since he made the decision to protect his government from the press the law has continued to evolve, and while the regulations have since loosened to give the media freedom, the idea behind the law remains constant. But can censorship be justified in a period, which by law (Article 10 of the Human Rights Act 1998)Read More Censorship in Media Essay2359 Words   |  10 Pagesviewing audience. Censorship is defined as Policy of restricting the public expression of ideas, opinions, conceptions, and impulses, which are believed to have the capacity to undermine the governing authority or the social and moral order which authority considers itself bound to protect? (Abraham 357). Political, religious, obscenity, and censorship affecting academic freedom are all equal in their destructiveness towards free speech. ?There are two different forms that censorship takes; prior, whichRead More America Needs Media Censorship Essay2288 Words   |  10 PagesAmerica Needs Media Censorship Introduction In a world in which acts of heinous violence, murder or crude and shocking behavior seem to be a normal occurrence, it may lead one to wonder what has put society onto this slippery slope. How did this type of behavior come to be so acceptable and in some cases glorifiable? A careful study of society may lead to multi media as being the main cause in this changing of ideals. The modern world has become desensitized to the acts shown on televisionRead MoreEssay about The Negative Impact of Media Censorship1905 Words   |  8 Pagesfreedoms using censorship to confine these rights that we usually take for granted. The most important facet of media in general is that it allows people to express themselves freely. In fact, this freedom of expression that music allows us is one of the primary reasons why it exists. Sadly, many of the current artists have forgotten that, but nonetheless, censorship seems to always be there to limit the expression of those who choose to place deeper messag es in their songs. Tackling censorship is muchRead More Media Censorship Essay examples662 Words   |  3 PagesMedia Censorship Today there is much controversy over whether there should or shouldn’t be censorship of the media. Censorship should not be imposed on citizens by the government or other agencies; adults have a right to view or listen to what they choose. Additionally, if children’s media is censored, parents are the ones who should monitor and regulate it. Parents should be the ones to monitor children’s viewing of television and also what they hear on the radio, CD’s, and tapes. CensorshipRead More Television and Media - Censorship of TV Violence Not Necessary877 Words   |  4 PagesCensorship of TV Violence Not Necessary    Censorship of televised media often begins as a result of the concern many adults show over what their children watch. Children begin watching television at an early age, and they are usually lifetime viewers by the time they are two to three years old. There is usually a steady increase in the amount of television watched during a persons childhood. This is followed by a decline during adolescence. What is more of a concern to the American peopleRead MoreCensorship Filters The Media Within The World1574 Words   |  7 PagesDoes censorship filter the media within the world? Censorship has followed the free expressions of men and women like a shadow throughout history. Censorship is a way to filter the media in the world by suppressing unacceptable viewings or hearings by not showing, bleeping out, and covering the distasteful parts. In ancient societies, China for example, censorship was considered a logical tool for regulating the political and moral life of the population. Th e term censor can be traced to the officeRead MoreMedia Censorship around the World2803 Words   |  12 PagesMedia censorship is not an unusual phenomenon around the world, as it has been disapproved by right groups since ancient times. It had originated in ancient times when rulers and religious leaders imposed limitation on the press, with an aim to stop them from spreading information which might turn against them, and the activities conducted by them. Regardless of the differences in geographical location, religion, culture and the tradition, the motive for censorship has remained the same. The most

Project Risk Management 420 Week 6 - 1105 Words

xxxxxxx PROJ 420 (A)/Fall A 11 Executive Summary Week 6 Assignment Executive Summary Due to economic strains our company is under more pressure than ever to deliver value and cannot afford to compromise productivity and efficiency. Our goal is to reduce the total cost and maximize efficiency within our office. We are continually seeking to maintain and improve our productivity and effectiveness in order to keep us from downsizing any department. Our task forces are implementing different processes that can help us find the less expensive way to meet our goal. Below we will discuss the possible risks and the recommendations to mitigate or eliminate those potential risks. We identified several risks and have assessed them in†¦show more content†¦Risk #1: Deficiency of skills - Risk of improper training. Status: RED Owner: Assistant of Supervisor of Operations Recommendations / Actions: * Allocate funds to properly train all staff. Target completion: 12/15. Risk #2: Changes – Risk that fluctuation of employees might impact visibility of scope. Status: Red Owner: Supervisor of Operations Recommendations/Actions: * Plan for retirees and establish communication within the staff. Target completion 12/1. Risk #3: Funding - The lack of appropriate funds to train and educate staff. Status: Amber Owner: Director Recommendation/Actions: * Establishing allocations. Target completion 12/1. Risk #4: Lack of clarity - The lack of clear and concise goals and or confusion about the goal of the scope. Status: Amber Owner: Assistant Director Recommendation/Actions: * Obtain feedback from staff. Target completion 12/9. Risk | Risk Category | Probability | Impact | Risk Score | Risk Rank | Risk Response | Owner | Lack of knowledge on proper usage of equipment | Technical | 3 | 5 | 15 | 1 | Training staff on the proper way to utilize and maximize the usage of all equipment. | Asst of Sup of Operations | Employees retiring and fired might impact schedules | External | 3 | 5 | 15 | 2 | Better planning in order to incorporate the flow of personnel within the company. | Supervisor of Operations | Confusion about the goal and scope of project | Management | 2 | 5 | 10 | 3 |Show MoreRelatedProj 420 Coursework Guide Week 1 - 7696 Words   |  3 PagesPROJ 420 Coursework Guide Week 1 - 7 Purchase here http://devrycourse.com/proj-420-coursework-guide-week-1-7 Product Description (PROJ 420 Project Risk Management) PROJ 420 Week 1 Course Project Assignment; Project Topic Proposal and Outline PROJ 420 Week 1 Discussion 1 Why Should We Practice Risk Management PROJ 420 Week 1 Discussion 2 The ATOM Risk Management Process PROJ 420 Week 2 Course Project Assignment; Project Sizing and Stakeholder Analysis PROJ 420 Week 2 DiscussionRead MoreProj 420 Entire Course Project Risk Management Essay631 Words   |  3 Pageshomeworkproviders.com/shop/proj-420-entire-course/ PROJ 420 ENTIRE COURSE PROJECT RISK MANAGEMENT PROJ 420 (PROJECT RISK MANAGEMENT) COMPLETE WORK – DEVRY PROJ 420 Week 1 Course Project Assignment Project Topic Proposal and Outline PROJ 420 Week 1 Discussion 1 Why Should We Practice Risk Management PROJ 420 Week 1 Discussion 2 The ATOM Risk Management Process PROJ 420 Week 2 Course Project Assignment; Project Sizing and Stakeholder Analysis PROJ 420 Week 2 Discussion 1 The InitiationRead MoreTIG Welding Essay example1469 Words   |  6 Pageswelded joints in stainless steels are also the main subject of the senior project which will be submitted at the end of this year. The objective of this proposal is to give information on the plan of the project about the mechanical behaviours of TIG welded joints in stainless steels, regarding on the research facilities, equipments, materials and the methods that will be followed and used during the preparation of this project. 1. TIG Welding TIG welding, which was developed in late 1920sRead MoreImplementing Agile And Non Profit Organizations Essay1696 Words   |  7 Pagesbusiness process and risk model designed to quickly and profitably transform an organization’s best new ideas into winning new products (Edgett, 2015, p. 1). A Stage-gate development system is remarkably simple: a series of information gathering stages followed by decision-making gates that break the development process into a predetermined set of manageable stages (Cooper, 2011). Image Footnote Here Each stage has prescribed or suggested set of actives that meet the project expectations in theRead MoreRheumatoid Arthritis1649 Words   |  7 Pages BIOL 121 CRN # 23143 Outline: Rheumatoid Arthritis 1. Introduction: Statement of problem Definition Symptoms Causes amp; risk factors 2. Body How are you diagnosis Research Medications Who will get rheumatoid arthritis? Testing 3. Conclusion Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. While inflammationRead MoreInterdisciplinary Education3785 Words   |  16 PagesMedical Students Dana L. Singla, PharmD; George E. MacKinnon III, PhD; Karen J. MacKinnon, RPh; Wisam Younis, PharmD; Ben Field, DO†  The purpose of this project was to demonstrate to pharmacy and osteopathic medical students the value of interdisciplinary education through participation in an interdisciplinary medication adherence project. Each pharmacy student, assuming the role of a pharmacist, was paired with a medical student acting as a physician with a needlestick exposure requiring HIVRead MoreTata Nano: the Peoples Car12280 Words   |  50 Pages9-710-420 REV: JUNE 3, 2010 KRISHNA PALEPU BHARAT ANAND RACHNA TAHILYANI Tat Nano – The Peopl Car ta o e le’s r dia k big. Ind must think small to stay b — Ra atan Tata, Cha airman Tata G Group In March 2009, Tata Motors India’s larg , s, gest automob company by sales lau bile unched the world’s cheap pest car, the Tata Nano i India price at $2500 (see Exhibit 1 for a pict in ed ture of the N Nano). Throu ugh this laun nch, the comp pany realized Tata Group Chairman R d Ratan Tata’s v visionRead MoreJadm 430 Complete Course - Devry ( All Assignments - Dqs and Midterm Exam)3666 Words   |  15 PagesAt JohnMate1122@gmail.com Course Project: Managing the Prison Environment Objectives Back to Top The Course Project is designed to provide you with an opportunity to research a topic of interest related to some aspect of correctional administration. This project is an effort to allow you to fully explore issues related to either correctional officials or prison inmates. This project incorporates all TCOs. Guidelines Back to Top The course project is worth 320 total points and will beRead MorePersonal Financial Plan2798 Words   |  12 Pagesï » ¿Financial Plan Project By ADM 3445 E. Otuteye March 31st, 2010 1. Personal Characteristics/Goals The following consist of a constructed financial plan for Tyler Sisson. He is a single 22 year old and is completing his fourth year in the business program at University of New Brunswick. He has an apartment on Montgomery street, were he walks to school everyday, and plans toRead MoreThe A380 Project Essay example4071 Words   |  17 PagesA380 project is one of the most complex projects to ever happen. An aircraft of such large size and complexity would always have problems. Although problems are always anticipated during such a large project, the management involved with this project mismanaged many aspects. The project’s success can be examined using many project management aspects. This report will analyse in particular the areas of project scheduling, stakeholder management and project leadership within the A380 project. The project

Biological Sciences and Statistics

Question: Discuss about the Biological Sciences and Statistics. Answer: Introduction According to GLOBOCON statistics, colon cancer is one of the most cancers accounting for 1.36 million of cases worldwide during the year 2012 (cancer.org, 2016). It is third common cancer in affecting men worldwide according to World Health Organization 2015 statistics (Siegel, Miller and Jemal, 2016). The colon cancer develops in the colon region in the large intestine (cancer.gov, 2016). The adenomatous polyps are generally benign being the pre-cancerous condition but can metastasize and could develop into cancer spreading outside the colon region (cancer.org 2016). The Familial Polyposis coli is one of the genetically predisposing condition causing colon cancer and characterized by thousands of polyp development in the colon (cancer.org, 2016). An individual has a lifetime risk of developing colon cancer to 100 % by the time they reaches the age of 40 (globocan.iarc.fr, 2016). The Familial Adenomatous Polyposis is an autosomal dominant disorder in which there is development of hun dreds of adenomatous polyps in the early stages of life throughout the colon (wcrf.org, 2016). If this condition persists and left untreated, the colon cancer is likely to develop by the age of 40. In the given case study of 40 year old Caucasian man (patient X) has a family history of Familial Adenomatous Polyposis (FAP) and at the age of 18 he was screened for Adenomatous Polyposis Coli gene 1 (APC 1). The Adenomatous Polyposis Coli 1 gene was sequenced and his colon cells were harvested and frozen. When he reached the age of 40 years, he showed symptoms like the abdominal pain, change in bowel habits and unexplained weight loss. Patient X underwent a biopsy of the colon tissue showed that there were hundreds of colorectal adenomatous polyps indicating Familial Polyposis Coli and the comparative study was done for cyclin D1 in the cells with his previous colon cells harvested at the age of 18. Quantitative polymerase chain reaction was done to analyze the results by cloning, sequencing and the following results were reported and interpreted for the patient X. Patient Codon Allele 1 Allele 2 Patient X 280 TCA TGA Father 280 TCA TCA Mother 280 TCA TGA The table 1 shows the sequence of Adenomatous Polyposis Coli 1 gene of patient X blood sample at the age of 18 including his mother and father. The adenomatous Polyposis coli 1 gene is a tumor suppressor gene that plays an important role in the development of colon cancer. The germ line mutation in the APC 1 gene located on 5q21-q22 band leads to Familial Adenomatous Polyposis that is hereditary colon cancer. The autosomal dominant pattern occurred in which one single altered copy of the gene is enough to cause the disorder. The genetic change meant that the codon 280 present on the exon 8 of adenomatous polyposis coli 1 gene underwent a codon change from TCA to TGA that is base pair mutation (Chromium.lovd.nl, 2016) It is a non-sense mutation in which TCA that codes for serine gets mutated to TGA that codes for stop codon. This APC gene mutated allele sequence shows that the mother has an altered copy of allele inherited from either of her parents. The patient X also inherited that altered copy of the allele from his mother and therefore showed predisposing condition of familial adenomatous polyposis at the age of 18. The other normal allele that is allele 1 coding for serine TCA has become inactivated either by deletion or mutation. The tumor suppressing function of the APC gene is lost and develops in the form of adenomatous polyps. It could be interpreted that at the age of 18, patient X underwent a mutation predisposing for the familial adenomatous polyps and was exposed to develop colon cancer in the later stage if left untreated. This figure 1A shows a biopsy of the normal colon of the patient X at the age of 18 years by performing colonoscopy. It was done to diagnose the patient X for any symptom that showed the symptoms for the predisposing familial adenomatous polyposis condition. As the patient X confirmed the germ line mutation inherited from his mother from the adenomatous polyposis coli 1 gene sequencing. The assessment of the normal biopsy is done on low and high parameters. The size, orientation, muscularis mucosa presence or absence, sub mucosa and mucosa cellularity are observed in the biopsy of colon tissue. The data could be interpreted for the normal histology of the colonic mucosa. The layers are arranged as mucosa, sub mucosa, muscularis propria called externa, sub serosa and serosa containing the loose connective tissue and mesothelial lining (Cerilli, L.A. and Greenson, J.K., 2012). The mucosa consists of tubular crypts that are aligned perpendicularly to the muscularis mucosa. There is a co nstant distance between the crypts and their inner diameter. The normal biopsy might show a little variation or branching in the intercryptal spacing, crypt architecture or occasional branching of the crypts that is considered normal. It is important to study the cellularity in the lamina propria layer surrounding the crypts. It generally consists of cells like eosinophils, plasma cells, lymphocytes and histiocytes. There is presence of normal epithelium and no depletion in the number of goblet cells. The figure 1B shows the biopsy of colon of patient X at the age of 40. The patient X experienced change in bowel habits, abdominal pain and unexplained weight loss. The biopsy showed abnormal growth formations. These conditions satisfied the symptoms of colon cancer in the patient X. When he was screened for the adenomatous polyposis coli 1 gene mutation, he was found to be positive. In his later life, he was left untreated. However, when he reached the age of forty years, he started developing the symptoms of colon cancer as he had a family history of colon cancer showing the genetic predisposing condition of familial adenomatous polyposis. When he was 18 years old, he started developing adenomatous polyps which were benign. Gradually, the pre-cancerous polyps started developing into carcinomas polyps. By the time he attended the age of 40, he developed abnormal outgrowths in the mucosa layer and developed colon cancer. The figure 1B showed tubular adenoma that are small adenomatous polyps on the small stalk that are viewed under the microscope showing disorganized, crowded mucosa of the colon. The goblet cells are less in number and showed hyper chromatic nuclei in the cells lining the polyp glands. This histology shows the benign conditions that are circumscribed, well-differentiated and there is not much invasion of the stalk. The differentiation of the neoplasm is defined by the small adenomatous polyps that are benign in the colon (Jass and Sobin 2012). The staining is done differentially in the epithelial cells present at the top of the adenoma and glandular epithelium that are normal present at the below of the mucosa in the colon. The well differentiated condition showed that the polyps are benign and not yet metastasized (Arqus et al. 2014). Differentiation is one of the variables that act as potential parameter in studying the biologic behaviour in the neoplasm. The figure 2 shows the indirect immunofluorescence and fluorescence microscopy of the stained colon cells of the patient to see the cells for the catenin. The catenin is an important protein associated with the adenomatous polyposis coli 1 gene. The catenin plays an important role in promoting the proliferation of cells and acts to control the activity and expression of the various genes. catenin also helps in the differentiation of the cells. The vital role that catenin plays is that it helps to attach the cells to one another and also in tissue formation. The catenin association with the adenomatous polyposis coli gene gives a signal to the catenin to break down and therefore it is no longer functional (Holland et al. 2013). The adenomatous polyposis coli gene acts as a negative regulator for catenin and also controls its concentration. Cadherin interacts with catenin and is involved in the cell adhesion mechanism. When the expression of catenin is seen in the immune fluo rescence microscopy by the antibody treatment to the precipitated adenomatous polyposis coli gene with the identification and sequencing of the beta-catenin is done (Clevers and Nusse 2012). This figure 2 showed the beta catenin expression and adenomatous polyposis coli is involved in the cell adhesion process. The Wnt signaling is activated during mutation that initiates the colon cancer. The beta catenin concentration in nucleus is a measure to show the stage of the colon cancer. The figure 3 shows the expression of the cyclin D1 levels at the mRNA level. The cyclin D1 levels are an indication of neoplasm in the colon. The quantitative polymerase chain reaction is an accurate tool to measure the levels of cyclin D1 expression at the mRNA level. Cyclin D1 plays an important role in the proliferation and continuity of cell cycle. The high expression of the cyclin D1 levels is an indication of the progression of cancer. It is basically a proto-oncogene and regulates the progression of the cell cycle from G1 to S phase. The cyclin D1 is a prognostic marker and helpful in assessing as it is the cell cycle checkpoints (Colussi et al. 2013). Cyclin D1 is activated when adenomatous polyposis coli gene is mutated and Wnt or beta catenin signaling is activated. This quantitative polymerase chain reaction of the cyclin D1 levels showed that the initiation of the neoplasm in the colon. The comparative study by quantitative polymerase chain reaction of patient X at the ag e of 18 and 40 years showed that the cyclin D1 levels increased at the RNA level at the age of 40 and the cyclin D1 levels decreased at the age of 40 when compared to the levels at 18 years. The table 2 shows the polymerase chain reaction results done to amplify both the copies of the patient X alleles of the adenomatous polyposis gene. The codon at the position 1338 shows a substitution and base pair mutation. It is a nonsense mutation as the allele 1 of the codon 1338 contains a stop codon that is an altered form of the two alleles of the adenomatous polyposis coli gene. The CAG codes for glutamine however, there is loss of function of the allele 2 and allele 1 has gain in function. There is loss of function of the adenomatous polyposis gene as a tumor suppressor and therefore, the mutation results in predisposing condition for progression of colon cancer. A new mutation occurred at the age of 40 in patient X and it is the actual time when he started showing the symptoms for the disease. The underlying molecular and genetic reason for patient X condition is the family history of colon cancers. The genetic predisposing condition familial adenomatous polyposis runs in the family with germ line mutation. The adenomatous polyposis coli 1 gene undergoes nonsense mutations at the codon 280 and 1338. The patient X inherited the defective allele from his mother undergoing a base pair mutation coding for stop codon. The codon 1338 also codes for stop codon from glutamine. The prognosis for patient X is that his family has a history of colon cancers. The patient X has a predisposing genetic condition that is the familial adenomatous polyposis. He inherited the defective allele from his mother and a new mutation at the age of 40 when he actually showed the symptoms for neoplasm colon cancer. The surgery would not be helpful for the patient s the polyps would continue to grow. However, removal of the polyps by colonoscopy would help to stop them from being cancerous. The non-steroidal anti-inflammatory diseases and the combination of celecoxib and cyclooxygenase 2 inhibitors would help to reduce the size of the polyps. References: Arqus, O., Chicote, I., Tenbaum, S., Puig, I. and Palmer, H.G., 2014. Quantitative procedure to analyze nuclear -catenin using immunofluorescence tissue staining. Protoc exch. cancer.gov, (2016). Genetics of Colorectal Cancer. [online] National Cancer Institute. Available at: https://www.cancer.gov/types/colorectal/hp/colorectal-genetics-pdq [Accessed 8 Dec. 2016]. cancer.org , (2016). [online] Available at: https://www.cancer.org/acs/groups/content/documents/document/acspc-042280.pdf [Accessed 8 Dec. 2016]. cancer.org, (2016). [online] Available at: https://www.cancer.org/acs/groups/content/documents/document/acspc-042280.pdf [Accessed 8 Dec. 2016]. cancer.org, (2016). Colon/Rectum Cancer | American Cancer Society. [online] Cancer.org. Available at: https://www.cancer.org/cancer/colonandrectumcancer/ [Accessed 8 Dec. 2016]. Cerilli, L.A. and Greenson, J.K., 2012. The differential diagnosis of colitis in endoscopic biopsy specimens: a review article. Archives of pathology laboratory medicine, 136(8), pp.854-864. Chromium.lovd.nl. (2016). Search unique variants - Colon cancer gene variant databases - Leiden Open Variation Database. [online] Available at: https://chromium.lovd.nl/LOVD2/colon_cancer/variants.php?select_db=APCaction=search_uniqueorder=Variant/DNA_reported,DESChide_col=show_col=all [Accessed 8 Dec. 2016]. Clevers, H. and Nusse, R., 2012. Wnt/-catenin signaling and disease.Cell,149(6), pp.1192-1205. Colussi, D., Brandi, G., Bazzoli, F. and Ricciardiello, L., 2013. Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention.International journal of molecular sciences,14(8), pp.16365-16385. globocan.iarc.fr, (2016). Fact Sheets by Cancer. [online] Globocan.iarc.fr. Available at: https://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx?cancer=colorectal https://onlinelibrary.wiley.com/doi/10.1002/ijc.29210/abstract [Accessed 8 Dec. 2016]. Holland, J.D., Klaus, A., Garratt, A.N. and Birchmeier, W., 2013. Wnt signaling in stem and cancer stem cells.Current opinion in cell biology,25(2), pp.254-264. Jass, J.R. and SOBIN, L., 2012.Histological typing of intestinal tumours. Springer Science Business Media. Siegel, R., Miller, K. and Jemal, A. (2016). Cancer statistics, 2016. wcrf.org, (2016). Colorectal cancer statistics | World Cancer Research Fund International. [online] Wcrf.org. Available at: https://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/colorectal-cancer-statistics [Accessed 8 Dec. 2016].

Supply Chain Game Assessment free essay sample

In our first encounter with the â€Å"Beer Game† there was a deliberate lack of information flow throughout the supply chain. This inability to access and analyze previous data and forecasts left all participants in the supply chain in the dark as to the right amount of stock to keep on hand and the ability to predict future fluctuations in the demand. Without this data to rely on many decisions were made from a panic mentality rather than a logical one. Communication within the supply chain is imperative and must be shared among all participants to allow each member to better evaluate their customer demands at high and low periods. In the second session of the â€Å"Beer Game†, all participants were allowed access and share data needed to make rational decisions rather than emotional ones. By having this information, the prices and inventories were kept at closer intervals and all members were able to adjust accordingly without panic, saving undue production and costs. We will write a custom essay sample on Supply Chain Game Assessment or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Having a demand forecast updating throughout the supply chain allows all participants the ability to fine-tune their inventories, reduce overheads and costs. Cisco in turn had the opportunity to secure all information and data needed to make good decisions but, in gathering information, it is only as good as a person that gathers it. After reading the article â€Å"What Happened to Cisco†, the information that was gathered was skewed toward the idea of cost growth. Cisco had begun to believe their own hype and believed that their systems were so efficient that they were infallible. The one thing Cisco did not model for was what would happen if the growth suddenly stopped. After four straight quarters of consistent growth, Cisco was never not growing. (3) The next issue facing the members of supply chain had to do with the time limitations and delivery schedules between orders. This effect, according to the article â€Å"The Bullwhip Effect in Supply Chains† was referred to as ‘order batching’. Order batching is when companies do not immediately place orders with their suppliers due to back-up stock on hand, or often accumulating the demand first and waiting until they can take advantage of full load discounts and promotions. Our window in the first game was 4 weeks. A major variability in demand in the 5th week created a surge in demand that was forecasted but overlooked by many. Without the proper data, the entire supply chain was caught off guard and there were shortages that rippled all the way back to the factory. â€Å"Periodic ordering amplifies variability and contributes to the bullwhip effect. † (1) Communication abilities in the second round allowed shorter delivery turn around, which led to less drastic variations in the ordering curve, no stock-outs, and no thirsty customers. Cisco also began to experience shortages in their supply of routers and switches. So they decided to increase the component inventory in order to reduce wait time for its customers, also giving them a reserve always to draw its component makers ran out. This behavior also corresponds with the fourth effect of the bullwhip known as rationing and shortage gaming. The sales staff continued reporting higher demands and forecasts which meant it was time to build up inventory. And then in the year 2000 largest recession since the Great Depression hits leaving Cisco with equipment that could not be delivered. (3) The third reason for The Bullwhip Effect according to the aforementioned article was price fluctuation. Although there was no price fluctuation in game one or in game two, we did see a major fluctuation in the ordering curve. The fluctuation in price and unforeseen order demands would have seriously affected the overall costs of products, stock-outs, and inventory. Also, having the ability to order without satisfying full order limits help to curtail logistics expenditures. Many of the problems seen in the bullwhip effect originate from large buy in quantities during promotions. It is at this time that many retailers will buy at lower prices anticipating future price increases. This extra buy in will create a ripple that affects everyone in the supply chain without the proper information and communication that will need to be documented. In other words, if a grocery store buys 2000 cases of soda in anticipation of two promotions, knowing that before the second promotion there will be a price increase, the mass quantity buy will increase the retailers overall profits but shows up on the sales data as a major fluctuation. Without knowing about the circumstance of the sale this could create a bullwhip effect. This occurrence happened quite often while I was involved in the beverage industry. The district manager would forecast a certain number of cases to be moved within a quarter; then the factory would ship according to the forecast, whether close or not. Problem was the forecast sometimes did not live up to the hype and at the end of the quarter many times the warehouse was overstocked with product that needed to be moved before the next shipment started for the beginning of the next sales quarter. This overstock lead to many major price reductions and incentives throughout the district so that most of the grocery stores were able to purchase large sums of stock and run supplement ads other than previously corporate contracted. Extra discounts equal lower costs which led to higher profits because many of the franchises did not reflect their savings in their everyday prices. With Cisco, there was no mention of any major price fluctuations other than when the bottom falls out in 2000. Instead of selling their switches and routers for full retail markup, they wind up settling for $. 15 on the dollar. (3) The final issue, rationing and shortage gaming, results when demand exceeds supply and manufacturers ration products on the basis of amounts ordered. Customers exaggerate their needs in an effort to get more products. When demands drop, customers will cancel their orders leaving the manufacturers stuck with the excess. This was not evident in the first game because of the lack of information available to the participating parties. In the second game, with more information and data available for review operating costs, inventory, and planning for greatly enhanced and reduced. Again this issue was prevalent in 1980s while I was involved in the beverage industry. Pepsi Cola had just introduced the Slice products in many of the stores found themselves without inventory and ordered larger quantities to build their stock. Shortly after, the program rapidly faded as just another flavored soft drink; leaving most warehouses with an overabundance of fruit sodas. Cisco was part of The Great Moderation because of its relation to changes in inventory management. Inventories were to act as a buffer between production and sales while excess of production over sales resulted in inventory accumulation. The Great Moderation was a belief that any major recession was a thing of the past. According to these explanations, the widespread adoption of information technology could have been brought about innovations in supply chain management. (4)