Friday, May 15, 2020

Literary Analysis The Kite Runner And Oedipus Rex

The Kite Runner Oedipus Rex: Literary Analysis Essay Although The Kite Runner and Oedipus Rex differ from the style in which they were written and by the authors who wrote them what they do share are common themes. Both the play and the book share two major subject matters. Guilt is one theme that is seen constantly between Amir dealing with it in The Kite Runner written by Khaled Hosseini and Oedipus and Jocasta’s struggle with it in Oedipus Rex written by Sophocles. Another theme found in both texts was strained family dynamics which shows readers a different look on family. The themes in the book and the play, although they are portrayed differently, both deal with family relationships, guilt and why it is significant from the†¦show more content†¦He was picked up and cared for by another family who he grew up thinking were his parents. This being said Oedipus did not have a relationship with his biological parents in a usual way. Oedipus married his mother Jocasta but at the time was not aware she was his mother a nd together they had children. Furthermore, the four children half girls half boys were developed through incest. To add to the dysfunction Oedipus figured out you cannot run from fate because he did kill Laius not knowing that was his father. This play transcends that not all families are perfect and hidden behind a â€Å"white picket fence† perfect, happy family there could be a mess that cannot be picked up and fixed. Another theme that was in both The Kite Runner and Oedipus Rex was guilt. Guilt in The Kite Runner is something that Amir knew all too well. Amir felt guilty from the very beginning of his life when his mother died during the childbirth and it got even worse when he thought Baba resented him. Amir’s guilt went to a new level when he witnessed Hassan being raped by Assef and did nothing to stop the situation except for running away. Adding on to the guilt, Amir had to deal with it after Ali and Hassan moved out because he contributed to the fact by letting Hassan take the blame for something that he did, straining once great relationships to non-existing relationships. Guilt did not just play a part in The KiteShow MoreRelatedDeveloping Management Skills404131 Words   |  1617 PagesLine 58 Understanding and Appreciating Individual Differences Important Areas of Self-Awareness 61 Emotional Intelligence 62 Values 65 Ethical Decision Making and Values 72 Cognitive Style 74 Attitudes Toward Change 76 Core Self-Evaluation 79 SKILL ANALYSIS 84 Cases Involving Self-Awareness 84 Communist Prison Camp 84 Computerized Exam 85 Decision Dilemmas 86 SKILL PRACTICE 89 Exercises for Improving Self-Awareness Through Self-Disclosure 89 Through the Looking Glass 89 Diagnosing Managerial Characteristics

Wednesday, May 6, 2020

Media Censorship - 1427 Words

April 30, 2011 Media Censorship in the United States Censorship has existed for longer than we could ever imagine. One of the first acts of state sponsored censorship occurred in 399 B.C. when Socrates, was executed for the â€Å"supposed common good of the people† (Guarding Public Morality, 2010, p.1). Socrates was a teacher and a philosopher in ancient Greece. His teaching methods were controversial for the time, and he was charged with corrupting the youth and drawing them away from the Greek religion. As a result of his actions, Socrates was sentenced to death by drinking a poisonous liquid containing hemlock (Guarding Public Morality, 2010, p. 1). As a teacher, Socrates had many students and one of those students, the Greek†¦show more content†¦This increase in violence and aggression leads to more crimes being committed by adults. This thinking leads to the theory that if there was more censorship, there would be less violence on television, and there would be less crimes being committed (Arguments Favoring, 2009, p.1). Those who are for media censorship are mostly conservatives who feel that violence and vulgarity should not be on the television because a child is likely to accidently or even purposely click over to that channel. Children’s critical thinking skills are not fully developed and they cannot comprehend information the way that adults do. Essentially, they feel that media censorship is essential in society to protect children from lost moral values (Arguments Favoring, 2009, p.1). On the other side of the debate, those against censorship of television feel that it is a violation of the Freedom of Speech which is the first amendment of the United States Constitution (Anti-Censorship, p.1). They argue that â€Å"Freedom of Speech is a basic human right, and that this should not be eroded or compromised through censorship in a nation which likes to call itself free† (Wilson, 2010, p.1). They also argue that the Freedom of Speech was not put into place to protect only the speech that the majority of people agreed with, rather it was put into place to protect the speech and opinions of all Americans (Anti-Censorship, p.2). Those against television censorship feel that it isShow MoreRelatedCensorship in the Media1115 Words   |  5 PagesIs Censorship necessary? â€Å"Once a government is committed to the principle of silencing the voice of opposition, it has only one way to go, and that is down the path of increasingly repressive measures, until it becomes a source of terror to all its citizens and creates a country where everyone lives in fear. -- Harry S Truman Thesis: Although some people believe that censorship is adequate to select what things does the society will be good and can live around it while others believe that thereRead MoreCensorship and Indecency in Media928 Words   |  4 PagesCensorship and Indecency in Media Although indecent speech is protected by the First Amendment speech in broadcast media has been restricted because of its accessibility to children. In Federal Communications Commission’s (FCC) current policy, indecent speech is defined as the â€Å"language that describes, in terms patently offensive as measured by contemporary community standards for the broadcast medium, sexual or excretory activities and organs, at times of the day when there is a reasonable thatRead MoreCensorship Of The Media By Herbert Foerstel3055 Words   |  13 Pagescovered such expression about any government officials† [Foerstel, 1998: 4] Censorship of the media - as described by Herbert Foerstel - took shape during the reign of King Edward I. Ever since he made the decision to protect his government from the press the law has continued to evolve, and while the regulations have since loosened to give the media freedom, the idea behind the law remains constant. But can censorship be justified in a period, which by law (Article 10 of the Human Rights Act 1998)Read More Censorship in Media Essay2359 Words   |  10 Pagesviewing audience. Censorship is defined as Policy of restricting the public expression of ideas, opinions, conceptions, and impulses, which are believed to have the capacity to undermine the governing authority or the social and moral order which authority considers itself bound to protect? (Abraham 357). Political, religious, obscenity, and censorship affecting academic freedom are all equal in their destructiveness towards free speech. ?There are two different forms that censorship takes; prior, whichRead More America Needs Media Censorship Essay2288 Words   |  10 PagesAmerica Needs Media Censorship Introduction In a world in which acts of heinous violence, murder or crude and shocking behavior seem to be a normal occurrence, it may lead one to wonder what has put society onto this slippery slope. How did this type of behavior come to be so acceptable and in some cases glorifiable? A careful study of society may lead to multi media as being the main cause in this changing of ideals. The modern world has become desensitized to the acts shown on televisionRead MoreEssay about The Negative Impact of Media Censorship1905 Words   |  8 Pagesfreedoms using censorship to confine these rights that we usually take for granted. The most important facet of media in general is that it allows people to express themselves freely. In fact, this freedom of expression that music allows us is one of the primary reasons why it exists. Sadly, many of the current artists have forgotten that, but nonetheless, censorship seems to always be there to limit the expression of those who choose to place deeper messag es in their songs. Tackling censorship is muchRead More Media Censorship Essay examples662 Words   |  3 PagesMedia Censorship Today there is much controversy over whether there should or shouldn’t be censorship of the media. Censorship should not be imposed on citizens by the government or other agencies; adults have a right to view or listen to what they choose. Additionally, if children’s media is censored, parents are the ones who should monitor and regulate it. Parents should be the ones to monitor children’s viewing of television and also what they hear on the radio, CD’s, and tapes. CensorshipRead More Television and Media - Censorship of TV Violence Not Necessary877 Words   |  4 PagesCensorship of TV Violence Not Necessary    Censorship of televised media often begins as a result of the concern many adults show over what their children watch. Children begin watching television at an early age, and they are usually lifetime viewers by the time they are two to three years old. There is usually a steady increase in the amount of television watched during a persons childhood. This is followed by a decline during adolescence. What is more of a concern to the American peopleRead MoreCensorship Filters The Media Within The World1574 Words   |  7 PagesDoes censorship filter the media within the world? Censorship has followed the free expressions of men and women like a shadow throughout history. Censorship is a way to filter the media in the world by suppressing unacceptable viewings or hearings by not showing, bleeping out, and covering the distasteful parts. In ancient societies, China for example, censorship was considered a logical tool for regulating the political and moral life of the population. Th e term censor can be traced to the officeRead MoreMedia Censorship around the World2803 Words   |  12 PagesMedia censorship is not an unusual phenomenon around the world, as it has been disapproved by right groups since ancient times. It had originated in ancient times when rulers and religious leaders imposed limitation on the press, with an aim to stop them from spreading information which might turn against them, and the activities conducted by them. Regardless of the differences in geographical location, religion, culture and the tradition, the motive for censorship has remained the same. The most

Project Risk Management 420 Week 6 - 1105 Words

xxxxxxx PROJ 420 (A)/Fall A 11 Executive Summary Week 6 Assignment Executive Summary Due to economic strains our company is under more pressure than ever to deliver value and cannot afford to compromise productivity and efficiency. Our goal is to reduce the total cost and maximize efficiency within our office. We are continually seeking to maintain and improve our productivity and effectiveness in order to keep us from downsizing any department. Our task forces are implementing different processes that can help us find the less expensive way to meet our goal. Below we will discuss the possible risks and the recommendations to mitigate or eliminate those potential risks. We identified several risks and have assessed them in†¦show more content†¦Risk #1: Deficiency of skills - Risk of improper training. Status: RED Owner: Assistant of Supervisor of Operations Recommendations / Actions: * Allocate funds to properly train all staff. Target completion: 12/15. Risk #2: Changes – Risk that fluctuation of employees might impact visibility of scope. Status: Red Owner: Supervisor of Operations Recommendations/Actions: * Plan for retirees and establish communication within the staff. Target completion 12/1. Risk #3: Funding - The lack of appropriate funds to train and educate staff. Status: Amber Owner: Director Recommendation/Actions: * Establishing allocations. Target completion 12/1. Risk #4: Lack of clarity - The lack of clear and concise goals and or confusion about the goal of the scope. Status: Amber Owner: Assistant Director Recommendation/Actions: * Obtain feedback from staff. Target completion 12/9. Risk | Risk Category | Probability | Impact | Risk Score | Risk Rank | Risk Response | Owner | Lack of knowledge on proper usage of equipment | Technical | 3 | 5 | 15 | 1 | Training staff on the proper way to utilize and maximize the usage of all equipment. | Asst of Sup of Operations | Employees retiring and fired might impact schedules | External | 3 | 5 | 15 | 2 | Better planning in order to incorporate the flow of personnel within the company. | Supervisor of Operations | Confusion about the goal and scope of project | Management | 2 | 5 | 10 | 3 |Show MoreRelatedProj 420 Coursework Guide Week 1 - 7696 Words   |  3 PagesPROJ 420 Coursework Guide Week 1 - 7 Purchase here http://devrycourse.com/proj-420-coursework-guide-week-1-7 Product Description (PROJ 420 Project Risk Management) PROJ 420 Week 1 Course Project Assignment; Project Topic Proposal and Outline PROJ 420 Week 1 Discussion 1 Why Should We Practice Risk Management PROJ 420 Week 1 Discussion 2 The ATOM Risk Management Process PROJ 420 Week 2 Course Project Assignment; Project Sizing and Stakeholder Analysis PROJ 420 Week 2 DiscussionRead MoreProj 420 Entire Course Project Risk Management Essay631 Words   |  3 Pageshomeworkproviders.com/shop/proj-420-entire-course/ PROJ 420 ENTIRE COURSE PROJECT RISK MANAGEMENT PROJ 420 (PROJECT RISK MANAGEMENT) COMPLETE WORK – DEVRY PROJ 420 Week 1 Course Project Assignment Project Topic Proposal and Outline PROJ 420 Week 1 Discussion 1 Why Should We Practice Risk Management PROJ 420 Week 1 Discussion 2 The ATOM Risk Management Process PROJ 420 Week 2 Course Project Assignment; Project Sizing and Stakeholder Analysis PROJ 420 Week 2 Discussion 1 The InitiationRead MoreTIG Welding Essay example1469 Words   |  6 Pageswelded joints in stainless steels are also the main subject of the senior project which will be submitted at the end of this year. The objective of this proposal is to give information on the plan of the project about the mechanical behaviours of TIG welded joints in stainless steels, regarding on the research facilities, equipments, materials and the methods that will be followed and used during the preparation of this project. 1. TIG Welding TIG welding, which was developed in late 1920sRead MoreImplementing Agile And Non Profit Organizations Essay1696 Words   |  7 Pagesbusiness process and risk model designed to quickly and profitably transform an organization’s best new ideas into winning new products (Edgett, 2015, p. 1). A Stage-gate development system is remarkably simple: a series of information gathering stages followed by decision-making gates that break the development process into a predetermined set of manageable stages (Cooper, 2011). Image Footnote Here Each stage has prescribed or suggested set of actives that meet the project expectations in theRead MoreRheumatoid Arthritis1649 Words   |  7 Pages BIOL 121 CRN # 23143 Outline: Rheumatoid Arthritis 1. Introduction: Statement of problem Definition Symptoms Causes amp; risk factors 2. Body How are you diagnosis Research Medications Who will get rheumatoid arthritis? Testing 3. Conclusion Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. While inflammationRead MoreInterdisciplinary Education3785 Words   |  16 PagesMedical Students Dana L. Singla, PharmD; George E. MacKinnon III, PhD; Karen J. MacKinnon, RPh; Wisam Younis, PharmD; Ben Field, DO†  The purpose of this project was to demonstrate to pharmacy and osteopathic medical students the value of interdisciplinary education through participation in an interdisciplinary medication adherence project. Each pharmacy student, assuming the role of a pharmacist, was paired with a medical student acting as a physician with a needlestick exposure requiring HIVRead MoreTata Nano: the Peoples Car12280 Words   |  50 Pages9-710-420 REV: JUNE 3, 2010 KRISHNA PALEPU BHARAT ANAND RACHNA TAHILYANI Tat Nano – The Peopl Car ta o e le’s r dia k big. Ind must think small to stay b — Ra atan Tata, Cha airman Tata G Group In March 2009, Tata Motors India’s larg , s, gest automob company by sales lau bile unched the world’s cheap pest car, the Tata Nano i India price at $2500 (see Exhibit 1 for a pict in ed ture of the N Nano). Throu ugh this laun nch, the comp pany realized Tata Group Chairman R d Ratan Tata’s v visionRead MoreJadm 430 Complete Course - Devry ( All Assignments - Dqs and Midterm Exam)3666 Words   |  15 PagesAt JohnMate1122@gmail.com Course Project: Managing the Prison Environment Objectives Back to Top The Course Project is designed to provide you with an opportunity to research a topic of interest related to some aspect of correctional administration. This project is an effort to allow you to fully explore issues related to either correctional officials or prison inmates. This project incorporates all TCOs. Guidelines Back to Top The course project is worth 320 total points and will beRead MorePersonal Financial Plan2798 Words   |  12 Pagesï » ¿Financial Plan Project By ADM 3445 E. Otuteye March 31st, 2010 1. Personal Characteristics/Goals The following consist of a constructed financial plan for Tyler Sisson. He is a single 22 year old and is completing his fourth year in the business program at University of New Brunswick. He has an apartment on Montgomery street, were he walks to school everyday, and plans toRead MoreThe A380 Project Essay example4071 Words   |  17 PagesA380 project is one of the most complex projects to ever happen. An aircraft of such large size and complexity would always have problems. Although problems are always anticipated during such a large project, the management involved with this project mismanaged many aspects. The project’s success can be examined using many project management aspects. This report will analyse in particular the areas of project scheduling, stakeholder management and project leadership within the A380 project. The project

Biological Sciences and Statistics

Question: Discuss about the Biological Sciences and Statistics. Answer: Introduction According to GLOBOCON statistics, colon cancer is one of the most cancers accounting for 1.36 million of cases worldwide during the year 2012 (cancer.org, 2016). It is third common cancer in affecting men worldwide according to World Health Organization 2015 statistics (Siegel, Miller and Jemal, 2016). The colon cancer develops in the colon region in the large intestine (cancer.gov, 2016). The adenomatous polyps are generally benign being the pre-cancerous condition but can metastasize and could develop into cancer spreading outside the colon region (cancer.org 2016). The Familial Polyposis coli is one of the genetically predisposing condition causing colon cancer and characterized by thousands of polyp development in the colon (cancer.org, 2016). An individual has a lifetime risk of developing colon cancer to 100 % by the time they reaches the age of 40 (globocan.iarc.fr, 2016). The Familial Adenomatous Polyposis is an autosomal dominant disorder in which there is development of hun dreds of adenomatous polyps in the early stages of life throughout the colon (wcrf.org, 2016). If this condition persists and left untreated, the colon cancer is likely to develop by the age of 40. In the given case study of 40 year old Caucasian man (patient X) has a family history of Familial Adenomatous Polyposis (FAP) and at the age of 18 he was screened for Adenomatous Polyposis Coli gene 1 (APC 1). The Adenomatous Polyposis Coli 1 gene was sequenced and his colon cells were harvested and frozen. When he reached the age of 40 years, he showed symptoms like the abdominal pain, change in bowel habits and unexplained weight loss. Patient X underwent a biopsy of the colon tissue showed that there were hundreds of colorectal adenomatous polyps indicating Familial Polyposis Coli and the comparative study was done for cyclin D1 in the cells with his previous colon cells harvested at the age of 18. Quantitative polymerase chain reaction was done to analyze the results by cloning, sequencing and the following results were reported and interpreted for the patient X. Patient Codon Allele 1 Allele 2 Patient X 280 TCA TGA Father 280 TCA TCA Mother 280 TCA TGA The table 1 shows the sequence of Adenomatous Polyposis Coli 1 gene of patient X blood sample at the age of 18 including his mother and father. The adenomatous Polyposis coli 1 gene is a tumor suppressor gene that plays an important role in the development of colon cancer. The germ line mutation in the APC 1 gene located on 5q21-q22 band leads to Familial Adenomatous Polyposis that is hereditary colon cancer. The autosomal dominant pattern occurred in which one single altered copy of the gene is enough to cause the disorder. The genetic change meant that the codon 280 present on the exon 8 of adenomatous polyposis coli 1 gene underwent a codon change from TCA to TGA that is base pair mutation (Chromium.lovd.nl, 2016) It is a non-sense mutation in which TCA that codes for serine gets mutated to TGA that codes for stop codon. This APC gene mutated allele sequence shows that the mother has an altered copy of allele inherited from either of her parents. The patient X also inherited that altered copy of the allele from his mother and therefore showed predisposing condition of familial adenomatous polyposis at the age of 18. The other normal allele that is allele 1 coding for serine TCA has become inactivated either by deletion or mutation. The tumor suppressing function of the APC gene is lost and develops in the form of adenomatous polyps. It could be interpreted that at the age of 18, patient X underwent a mutation predisposing for the familial adenomatous polyps and was exposed to develop colon cancer in the later stage if left untreated. This figure 1A shows a biopsy of the normal colon of the patient X at the age of 18 years by performing colonoscopy. It was done to diagnose the patient X for any symptom that showed the symptoms for the predisposing familial adenomatous polyposis condition. As the patient X confirmed the germ line mutation inherited from his mother from the adenomatous polyposis coli 1 gene sequencing. The assessment of the normal biopsy is done on low and high parameters. The size, orientation, muscularis mucosa presence or absence, sub mucosa and mucosa cellularity are observed in the biopsy of colon tissue. The data could be interpreted for the normal histology of the colonic mucosa. The layers are arranged as mucosa, sub mucosa, muscularis propria called externa, sub serosa and serosa containing the loose connective tissue and mesothelial lining (Cerilli, L.A. and Greenson, J.K., 2012). The mucosa consists of tubular crypts that are aligned perpendicularly to the muscularis mucosa. There is a co nstant distance between the crypts and their inner diameter. The normal biopsy might show a little variation or branching in the intercryptal spacing, crypt architecture or occasional branching of the crypts that is considered normal. It is important to study the cellularity in the lamina propria layer surrounding the crypts. It generally consists of cells like eosinophils, plasma cells, lymphocytes and histiocytes. There is presence of normal epithelium and no depletion in the number of goblet cells. The figure 1B shows the biopsy of colon of patient X at the age of 40. The patient X experienced change in bowel habits, abdominal pain and unexplained weight loss. The biopsy showed abnormal growth formations. These conditions satisfied the symptoms of colon cancer in the patient X. When he was screened for the adenomatous polyposis coli 1 gene mutation, he was found to be positive. In his later life, he was left untreated. However, when he reached the age of forty years, he started developing the symptoms of colon cancer as he had a family history of colon cancer showing the genetic predisposing condition of familial adenomatous polyposis. When he was 18 years old, he started developing adenomatous polyps which were benign. Gradually, the pre-cancerous polyps started developing into carcinomas polyps. By the time he attended the age of 40, he developed abnormal outgrowths in the mucosa layer and developed colon cancer. The figure 1B showed tubular adenoma that are small adenomatous polyps on the small stalk that are viewed under the microscope showing disorganized, crowded mucosa of the colon. The goblet cells are less in number and showed hyper chromatic nuclei in the cells lining the polyp glands. This histology shows the benign conditions that are circumscribed, well-differentiated and there is not much invasion of the stalk. The differentiation of the neoplasm is defined by the small adenomatous polyps that are benign in the colon (Jass and Sobin 2012). The staining is done differentially in the epithelial cells present at the top of the adenoma and glandular epithelium that are normal present at the below of the mucosa in the colon. The well differentiated condition showed that the polyps are benign and not yet metastasized (Arqus et al. 2014). Differentiation is one of the variables that act as potential parameter in studying the biologic behaviour in the neoplasm. The figure 2 shows the indirect immunofluorescence and fluorescence microscopy of the stained colon cells of the patient to see the cells for the catenin. The catenin is an important protein associated with the adenomatous polyposis coli 1 gene. The catenin plays an important role in promoting the proliferation of cells and acts to control the activity and expression of the various genes. catenin also helps in the differentiation of the cells. The vital role that catenin plays is that it helps to attach the cells to one another and also in tissue formation. The catenin association with the adenomatous polyposis coli gene gives a signal to the catenin to break down and therefore it is no longer functional (Holland et al. 2013). The adenomatous polyposis coli gene acts as a negative regulator for catenin and also controls its concentration. Cadherin interacts with catenin and is involved in the cell adhesion mechanism. When the expression of catenin is seen in the immune fluo rescence microscopy by the antibody treatment to the precipitated adenomatous polyposis coli gene with the identification and sequencing of the beta-catenin is done (Clevers and Nusse 2012). This figure 2 showed the beta catenin expression and adenomatous polyposis coli is involved in the cell adhesion process. The Wnt signaling is activated during mutation that initiates the colon cancer. The beta catenin concentration in nucleus is a measure to show the stage of the colon cancer. The figure 3 shows the expression of the cyclin D1 levels at the mRNA level. The cyclin D1 levels are an indication of neoplasm in the colon. The quantitative polymerase chain reaction is an accurate tool to measure the levels of cyclin D1 expression at the mRNA level. Cyclin D1 plays an important role in the proliferation and continuity of cell cycle. The high expression of the cyclin D1 levels is an indication of the progression of cancer. It is basically a proto-oncogene and regulates the progression of the cell cycle from G1 to S phase. The cyclin D1 is a prognostic marker and helpful in assessing as it is the cell cycle checkpoints (Colussi et al. 2013). Cyclin D1 is activated when adenomatous polyposis coli gene is mutated and Wnt or beta catenin signaling is activated. This quantitative polymerase chain reaction of the cyclin D1 levels showed that the initiation of the neoplasm in the colon. The comparative study by quantitative polymerase chain reaction of patient X at the ag e of 18 and 40 years showed that the cyclin D1 levels increased at the RNA level at the age of 40 and the cyclin D1 levels decreased at the age of 40 when compared to the levels at 18 years. The table 2 shows the polymerase chain reaction results done to amplify both the copies of the patient X alleles of the adenomatous polyposis gene. The codon at the position 1338 shows a substitution and base pair mutation. It is a nonsense mutation as the allele 1 of the codon 1338 contains a stop codon that is an altered form of the two alleles of the adenomatous polyposis coli gene. The CAG codes for glutamine however, there is loss of function of the allele 2 and allele 1 has gain in function. There is loss of function of the adenomatous polyposis gene as a tumor suppressor and therefore, the mutation results in predisposing condition for progression of colon cancer. A new mutation occurred at the age of 40 in patient X and it is the actual time when he started showing the symptoms for the disease. The underlying molecular and genetic reason for patient X condition is the family history of colon cancers. The genetic predisposing condition familial adenomatous polyposis runs in the family with germ line mutation. The adenomatous polyposis coli 1 gene undergoes nonsense mutations at the codon 280 and 1338. The patient X inherited the defective allele from his mother undergoing a base pair mutation coding for stop codon. The codon 1338 also codes for stop codon from glutamine. The prognosis for patient X is that his family has a history of colon cancers. The patient X has a predisposing genetic condition that is the familial adenomatous polyposis. He inherited the defective allele from his mother and a new mutation at the age of 40 when he actually showed the symptoms for neoplasm colon cancer. The surgery would not be helpful for the patient s the polyps would continue to grow. However, removal of the polyps by colonoscopy would help to stop them from being cancerous. The non-steroidal anti-inflammatory diseases and the combination of celecoxib and cyclooxygenase 2 inhibitors would help to reduce the size of the polyps. References: Arqus, O., Chicote, I., Tenbaum, S., Puig, I. and Palmer, H.G., 2014. Quantitative procedure to analyze nuclear -catenin using immunofluorescence tissue staining. Protoc exch. cancer.gov, (2016). Genetics of Colorectal Cancer. [online] National Cancer Institute. Available at: https://www.cancer.gov/types/colorectal/hp/colorectal-genetics-pdq [Accessed 8 Dec. 2016]. cancer.org , (2016). [online] Available at: https://www.cancer.org/acs/groups/content/documents/document/acspc-042280.pdf [Accessed 8 Dec. 2016]. cancer.org, (2016). [online] Available at: https://www.cancer.org/acs/groups/content/documents/document/acspc-042280.pdf [Accessed 8 Dec. 2016]. cancer.org, (2016). Colon/Rectum Cancer | American Cancer Society. [online] Cancer.org. Available at: https://www.cancer.org/cancer/colonandrectumcancer/ [Accessed 8 Dec. 2016]. Cerilli, L.A. and Greenson, J.K., 2012. The differential diagnosis of colitis in endoscopic biopsy specimens: a review article. Archives of pathology laboratory medicine, 136(8), pp.854-864. Chromium.lovd.nl. (2016). Search unique variants - Colon cancer gene variant databases - Leiden Open Variation Database. [online] Available at: https://chromium.lovd.nl/LOVD2/colon_cancer/variants.php?select_db=APCaction=search_uniqueorder=Variant/DNA_reported,DESChide_col=show_col=all [Accessed 8 Dec. 2016]. Clevers, H. and Nusse, R., 2012. Wnt/-catenin signaling and disease.Cell,149(6), pp.1192-1205. Colussi, D., Brandi, G., Bazzoli, F. and Ricciardiello, L., 2013. Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention.International journal of molecular sciences,14(8), pp.16365-16385. globocan.iarc.fr, (2016). Fact Sheets by Cancer. [online] Globocan.iarc.fr. Available at: https://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx?cancer=colorectal https://onlinelibrary.wiley.com/doi/10.1002/ijc.29210/abstract [Accessed 8 Dec. 2016]. Holland, J.D., Klaus, A., Garratt, A.N. and Birchmeier, W., 2013. Wnt signaling in stem and cancer stem cells.Current opinion in cell biology,25(2), pp.254-264. Jass, J.R. and SOBIN, L., 2012.Histological typing of intestinal tumours. Springer Science Business Media. Siegel, R., Miller, K. and Jemal, A. (2016). Cancer statistics, 2016. wcrf.org, (2016). Colorectal cancer statistics | World Cancer Research Fund International. [online] Wcrf.org. Available at: https://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/colorectal-cancer-statistics [Accessed 8 Dec. 2016].

Tuesday, May 5, 2020

Supply Chain Game Assessment free essay sample

In our first encounter with the â€Å"Beer Game† there was a deliberate lack of information flow throughout the supply chain. This inability to access and analyze previous data and forecasts left all participants in the supply chain in the dark as to the right amount of stock to keep on hand and the ability to predict future fluctuations in the demand. Without this data to rely on many decisions were made from a panic mentality rather than a logical one. Communication within the supply chain is imperative and must be shared among all participants to allow each member to better evaluate their customer demands at high and low periods. In the second session of the â€Å"Beer Game†, all participants were allowed access and share data needed to make rational decisions rather than emotional ones. By having this information, the prices and inventories were kept at closer intervals and all members were able to adjust accordingly without panic, saving undue production and costs. We will write a custom essay sample on Supply Chain Game Assessment or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Having a demand forecast updating throughout the supply chain allows all participants the ability to fine-tune their inventories, reduce overheads and costs. Cisco in turn had the opportunity to secure all information and data needed to make good decisions but, in gathering information, it is only as good as a person that gathers it. After reading the article â€Å"What Happened to Cisco†, the information that was gathered was skewed toward the idea of cost growth. Cisco had begun to believe their own hype and believed that their systems were so efficient that they were infallible. The one thing Cisco did not model for was what would happen if the growth suddenly stopped. After four straight quarters of consistent growth, Cisco was never not growing. (3) The next issue facing the members of supply chain had to do with the time limitations and delivery schedules between orders. This effect, according to the article â€Å"The Bullwhip Effect in Supply Chains† was referred to as ‘order batching’. Order batching is when companies do not immediately place orders with their suppliers due to back-up stock on hand, or often accumulating the demand first and waiting until they can take advantage of full load discounts and promotions. Our window in the first game was 4 weeks. A major variability in demand in the 5th week created a surge in demand that was forecasted but overlooked by many. Without the proper data, the entire supply chain was caught off guard and there were shortages that rippled all the way back to the factory. â€Å"Periodic ordering amplifies variability and contributes to the bullwhip effect. † (1) Communication abilities in the second round allowed shorter delivery turn around, which led to less drastic variations in the ordering curve, no stock-outs, and no thirsty customers. Cisco also began to experience shortages in their supply of routers and switches. So they decided to increase the component inventory in order to reduce wait time for its customers, also giving them a reserve always to draw its component makers ran out. This behavior also corresponds with the fourth effect of the bullwhip known as rationing and shortage gaming. The sales staff continued reporting higher demands and forecasts which meant it was time to build up inventory. And then in the year 2000 largest recession since the Great Depression hits leaving Cisco with equipment that could not be delivered. (3) The third reason for The Bullwhip Effect according to the aforementioned article was price fluctuation. Although there was no price fluctuation in game one or in game two, we did see a major fluctuation in the ordering curve. The fluctuation in price and unforeseen order demands would have seriously affected the overall costs of products, stock-outs, and inventory. Also, having the ability to order without satisfying full order limits help to curtail logistics expenditures. Many of the problems seen in the bullwhip effect originate from large buy in quantities during promotions. It is at this time that many retailers will buy at lower prices anticipating future price increases. This extra buy in will create a ripple that affects everyone in the supply chain without the proper information and communication that will need to be documented. In other words, if a grocery store buys 2000 cases of soda in anticipation of two promotions, knowing that before the second promotion there will be a price increase, the mass quantity buy will increase the retailers overall profits but shows up on the sales data as a major fluctuation. Without knowing about the circumstance of the sale this could create a bullwhip effect. This occurrence happened quite often while I was involved in the beverage industry. The district manager would forecast a certain number of cases to be moved within a quarter; then the factory would ship according to the forecast, whether close or not. Problem was the forecast sometimes did not live up to the hype and at the end of the quarter many times the warehouse was overstocked with product that needed to be moved before the next shipment started for the beginning of the next sales quarter. This overstock lead to many major price reductions and incentives throughout the district so that most of the grocery stores were able to purchase large sums of stock and run supplement ads other than previously corporate contracted. Extra discounts equal lower costs which led to higher profits because many of the franchises did not reflect their savings in their everyday prices. With Cisco, there was no mention of any major price fluctuations other than when the bottom falls out in 2000. Instead of selling their switches and routers for full retail markup, they wind up settling for $. 15 on the dollar. (3) The final issue, rationing and shortage gaming, results when demand exceeds supply and manufacturers ration products on the basis of amounts ordered. Customers exaggerate their needs in an effort to get more products. When demands drop, customers will cancel their orders leaving the manufacturers stuck with the excess. This was not evident in the first game because of the lack of information available to the participating parties. In the second game, with more information and data available for review operating costs, inventory, and planning for greatly enhanced and reduced. Again this issue was prevalent in 1980s while I was involved in the beverage industry. Pepsi Cola had just introduced the Slice products in many of the stores found themselves without inventory and ordered larger quantities to build their stock. Shortly after, the program rapidly faded as just another flavored soft drink; leaving most warehouses with an overabundance of fruit sodas. Cisco was part of The Great Moderation because of its relation to changes in inventory management. Inventories were to act as a buffer between production and sales while excess of production over sales resulted in inventory accumulation. The Great Moderation was a belief that any major recession was a thing of the past. According to these explanations, the widespread adoption of information technology could have been brought about innovations in supply chain management. (4)

Monday, April 13, 2020

Animal Farm Summary

Animal Farm Summary George Orwells Animal Farm is an allegorical novel about a group of farm animals who take over their farm in 1940s England. Through the story of the animals revolution and its aftermath, Orwell assesses the failures of the communist revolution in Russia. Chapters 1-2 The novel opens at Manor Farm, where Mr. Jones, the cruel and incompetent farmer, is drunkenly going to sleep. As soon as the lights in the farmhouse go out, the animals gather. Old Major, an elderly boar whos lived on the farm for a long time, has called a meeting. At the meeting, Old Major describes a dream he had the previous night, in which the animals lived together without humans. He then launches into an impassioned speech. In the speech, he argues that humans are the enemies of all animals, and he urges the animals of the farm to organize and rebel against the humans. Old Major teaches the animals- who have varying degrees of intelligence- a song called Beasts of England in order to instill a sense of revolutionary fervor in them. Old Major passes away three days later. Three pigs named Napoleon, Snowball, and Squealer use this sad event to rally the animals. When the animals, who are starving, break into the store shed, Mr. Jones attempts to whip them. The animals revolt and drive Mr. Jones, his family, and his employees off the farm in terror. Napoleon and Snowball quickly organize the animals and remind them of Old Major’s teachings. They give the farm a new name- Animal Farm- and hold a meeting to vote on rules. Seven fundamental principles are adopted: Whatever goes upon two legs is an enemy.Whatever goes upon four legs, or has wings, is a friend.No animal shall wear clothes.No animal shall sleep in a bed.No animal shall drink alcohol.No animal shall kill any other animal.All animals are equal. Snowball and Napoleon order that these principles of Animalism be painted on the side of the barn in large white letters. The cart-horse, Boxer, is particularly excited and declares that his personal motto will be â€Å"I Will Work Harder.† Napoleon does not join the animals in the harvest, and when they return, the milk has disappeared. Chapters 3-4 Snowball undertakes a project to teach all the animals on the farm how to read and write. Napoleon takes charge of a litter of young puppies in order to teach them the principles of Animalism. He takes the puppies away; the other animals never see them. The animals work together and know the business of the farm very well. For a time, the farm is peaceful and happy. Every Sunday, Snowball and Napoleon gather the animals for a meeting in which they debate what to do next and vote. The pigs are the smartest of the animals, and so they assume leadership and create the agenda every week. Snowball has many ideas for improving the farm and the lives of the animals, but Napoleon is against almost all of his ideas. When the animals complain that they cannot remember so many of Animalism’s commandments, Snowball tells them that all they have to remember is â€Å"Four legs good, two legs bad.† Neighboring farmers are afraid that a similar overthrow could take place on their own farms. They band together with Mr. Jones to attack the farm with a gun. Snowball thinks quickly and organizes the animals into an ambush; they surprise the men and chase them off. The animals celebrate the â€Å"Battle of the Cowshed† and confiscate the gun. They decide to fire the gun once a year to commemorate the battle, and Snowball is hailed as a hero. Chapters 5-6 At the next Sunday meeting, Snowball suggests building a windmill, which will provide electricity as well as grind grain. He makes a passionate speech arguing that the windmill will make their lives easier. Napoleon gives a short speech opposing the matter, but he can tell he has lost the argument. Napoleon makes a sound, and suddenly the dogs he took away for education- now fully grown- burst into the barn, snarling and biting. They chase Snowball away. Napoleon tells the other animals that Snowball was their enemy and had been working with Mr. Jones. He announces that the meetings are no longer necessary, and that Napoleon, Squealer, and the other pigs will run the farm for the benefit of everyone. Napoleon decides to build the windmill after all. Work commences on the windmill- Boxer works especially hard at it, excited at the easier life they will have when it is done. The animals notice that Napoleon and the other pigs begin to act more like men: standing on their hind legs, drinking whiskey, and living inside. Whenever someone points out that this behavior violates the principles of Animalism, Squealer explains why they are wrong. Napoleons leadership becomes increasingly totalitarian. When a storm causes the windmill to collapse, Napoleon deflects blame by telling everyone that Snowball sabotaged it. He corrects the animals about their memory of the Battle of the Cowshed, insisting he was the hero they all remember, and that Snowball was in league with Mr. Jones. He accuses various animals of being in league with Snowball; his dogs attack and kill each one he accuses. Boxer accepts Napoleons rule, repeating â€Å"Napoleon is always right† as a mantra as he works harder and harder. Chapters 7-8 The windmill is rebuilt, but another farmer, Mr. Frederick, gets into a disagreement over a business deal with Napoleon and uses explosives to destroy the new windmill. Another battle ensues between the animals and the men. The men are once again driven away, but Boxer is severely injured. The animals discover Squealer with a can of white paint; they suspect the Animalism principles painted on the barn have been altered. Chapters 9-10 Boxer continues to work, driving himself to do even more despite his injuries. He grows weaker, and eventually collapses. Napoleon tells the animals he will send for a veterinary hospital to come get Boxer, but when the truck arrives, the animals read the words on the truck and realize Boxer is being sent to the ‛knacker’ to be made into glue. Napoleon has sold Boxer for whiskey money. Napoleon and Squealer deny this and claim that the truck had recently been purchased by the hospital and hadn’t been repainted. Later, Napoleon tells the animals that Boxer passed away under a doctor’s care. Time passes. The windmill is rebuilt again and generates a lot of income for the farm, but the lives of the animals get worse. No longer is there talk of heated stalls and electric lights for all. Instead, Napoleon tells the animals that the simpler their lives are, the happier they’ll be. Most of the animals who knew the farm before the revolution are gone. One by one, the principles of Animalism have been erased on the side of the barn, until only one remains: â€Å"All animals are equal, but some animals are more equal than others.† The simplified motto has been changed to â€Å"Four legs good, two legs better.† The pigs have become almost indistinguishable from the men: they live inside, wear clothes, and sleep in beds. Napoleon invites a neighboring farmer to dinner to discuss an alliance, and changes the name of the farm back to Manor Farm. Some of the animals peer into the farmhouse through the windows and cannot tell which are the pigs and which are the men.

Saturday, April 11, 2020

Persuasive Essay Examples - Write and Compete For A Scholarship

Persuasive Essay Examples - Write and Compete For A ScholarshipWhen you are considering writing a persuasive essay for your Th Grade Math Placement Test, you may need a lot of persuasive essays. The ability to persuade others to work in a specific way is a strong foundation for what an excellent teacher can do with your students. You can have wonderful persuasive results if you use persuasive essay samples.I teach classes in the humanities and the sciences, as well as classes specifically designed for children, teens, and adults. I am concerned about the way people think about ideas and questions. In the classroom, I often remind my students that we are all thinking in rational or scientific ways. To make our thinking more productive, I encourage my students to write persuasive essays based on logic.There are a number of persuasive essay samples that you can find online. Some are free, but I prefer the ones with paid versions that have excellent persuasive scripts and ideas. Paying f or an essay or homework assignment is important because it allows you to have real information and not just 'just reading the words on the page.'A simple persuasive essay sample may include the following basic idea: 'Research has shown that the human mind and body are built for communication. Every person has a unique set of communication skills. Many of them are working at exactly the right time to help us use our communication abilities in a positive way. People around the world are using humor, tone, and style to help communicate better.These persuasive essay samples are great because they start out with specific ideas, such as to start a conversation with a high level of eye contact and calmness, or to do some kind of political statement, or to write a persuasive article. The key to successful persuasive writing is to be able to quickly come up with an effective theme, which leads to a strong supporting argument. This is the big differencebetween high and low-level communication skills.By being able to use these persuasive essay samples, you will be able to get better grades for a number of reasons. When you write a persuasive essay that has some really good ideas and an interesting beginning, you will build the courage to write. If you can't get through your first paragraph, you will continue to work harder and you will eventually write a persuasive essay that is lively and interesting. This helps to move along the student's communication skill and provides them with a larger variety of expressive ideas that they can bring to the class.The great thing about persuasive essay samples is that they help you understand the impact of writing based on arguments and points of view. These persuasive essays are helpful in improving your writing skills, and also provide you with practice with different kinds of writing that you can use as examples throughout your life. If you are looking for more persuasive essays, you should look for samples online that you can dow nload.